Gameplay combines surgical simulation with a story told as a visual novel, with operations and control options reworked for the Wii hardware. Second Opinion expands on the original narrative through the perspective of Naomi Kimishima, another doctor with the Healing Touch. Set in a near future where medical science can cure previously incurable diseases, the story follows young surgeon Derek Stiles as he uses his mystical "Healing Touch" to treat a new disease dubbed GUILT. The game was released in North America and Japan in 2006 by Atlus as a console launch title, and in other regions in 2007 by Nintendo.
The second entry in the Trauma Center series, Second Opinion is a remake of the Nintendo DS title Trauma Center: Under the Knife (2005). Trauma Center: Second Opinion is a simulation video game developed by Atlus for the Wii.
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